Asthma Research Today is a free monthly online journal that collates and summarizes the latest research about Asthma, including details on symptoms, diagnosis, treatment, causes, medications.

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. rekgt@channing.harvard.edu

Published 13 October 2011 in N Engl J Med, 365(13): 1173-83.
Full-text of this article is available online (may require subscription).

Articles on Asthma published 13 October 2011:

Lebrikizumab treatment in adults with asthma.   N Engl J Med, 365(12): 1088-98.

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Articles on Asthma published 5 October 2011:

Hospital-level compliance with asthma care quality measures at children's hospitals and subsequent asthma-related outcomes.   JAMA, 306(13): 1454-60.

[Abstract] [Full-text]

Articles on Asthma published 27 September 2011:

First- and second-trimester fetal size and asthma outcomes at age 10 years.   Am J Respir Crit Care Med, 184(4): 407-13.

[Abstract] [Full-text]

Articles on Asthma published 13 September 2011:

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.   J Clin Invest, 121(8): 3133-43.

Asthma is considered a Th2 cell–associated disorder. Despite this, both the Th1 cell–associated cytokine IFN-γ and airway neutrophilia have been implicated in severe asthma. To investigate the relative contributions of different immune system components to the pathogenesis of asthma, we previously developed a model that exhibits several features of severe asthma in humans, including airway neutrophilia and increased lung IFN-γ. In the present studies, we tested the hypothesis that IFN-γ ... [Abstract] [Full-text]

Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells.   J Clin Invest, 121(8): 3088-93.

Atopic asthma is a chronic disease of the airways that has taken on epidemic proportions in the industrialized world. The increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach, from Western societies. In this study, we have utilized mouse models of allergic airway disease induced by ovalbumin or house dust mite allergen to experimentally examine a possible inverse ... [Abstract] [Full-text]

Articles on Asthma published 12 September 2011:

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.   Lancet, 378(9795): 1006-14.

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Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial.   Lancet, 378(9795): 983-90.

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Articles on Asthma published 31 August 2011:

The role of the primary care physician in helping adolescent and adult patients improve asthma control.   Mayo Clin Proc, 86(9): 894-902.

Many adolescents and adults with asthma continue to have poorly controlled disease, often attributable to poor adherence to asthma therapy. Failure to adhere to recommended treatment may result from a desire to avoid regular reliance on medications, inappropriate high tolerance of asthma symptoms, failure to perceive the chronic nature of asthma, and poor inhaler technique. Primary care physicians need to find opportunities and methods to address these and other issues related to poor asthma ... [Abstract] [Full-text]

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